Controlling the immune system

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Controlling the immune system

Controlling the Immune Response
Problems between the brain and the immune system can go the other way, too. If for some reason you're unable to make enough of these brain stress hormones, you won't be able to turn off the immune cells once they're no longer needed.

"There has to be an exit strategy for these battles that are being fought by the immune system, and the brain provides the exit strategy through stress hormones," Dr. Sternberg says. "If your brain can't make enough of these hormones to turn the immune system off when it doesn't have to be active anymore, then it could go on unchecked and result in autoimmune diseases like rheumatoid arthritis, lupus, or other autoimmune diseases that people recognize as inflammation."

Dr. Sternberg says that there are several factors involved in these autoimmune conditions. There are many different effects that the brain and its nervous system can have on the immune system, depending on the kinds of nerve chemicals that are being made, where they're being made, what kind of nerves they come from, and whether they're in the bloodstream or not. Still, at least part of the problem in these diseases seems to involve the brain's hormonal stress response.

"So if you have too much stress hormone shutting down the immune response, you can't fight off infection and you're more susceptible to infection," Dr. Sternberg concludes. "Too little stress hormones and the immune response goes on unchecked and you could get an inflammatory disease."

to be continued ...
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