Fixing the pain

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Fixing the pain

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At Yale, Waxman and colleagues are identifying what happens to nerve cells to cause the intense pain experienced by up to half of spinal cord injury victims. They have zeroed in on a molecule that may provide a target for drug therapy and other strategies.

Waxman's team also is focusing on restoring nerve fibers by replacing their protective coating, called the myelin sheath, which helps to speed nerve impulses.

"All spinal cord researchers agree that it looks like you need only 10% to 15% of the nerve fibers ... to have some degree of usable gait," he says. "Now, you're not going to be doing a ballet dance, but you tell that to Christopher Reeve. If he could walk 15 feet, that would be a major advance in terms of his quality of life."

Progress will come in increments. "Can we take someone paralyzed from the neck down and give them use of their shoulders? Can we get someone to walk four or five steps? I think those have turned into realistic objectives."

People with spinal cord injuries should not give up hope.

"When I was a kid, I wanted to be an astronomer, and I asked my dad if men could ever walk on the moon," Waxman says. "He said, 'That's impossible.' Years later, I remember being a med student and with my wife watching men walk on the moon.

"The impossible is now possible. It may not happen overnight, but we now have the tools."


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